One-Pot Synthesis of Substituted Pyridine

Abstract

The studies on application of magnetically separable substituted nano ferrites towards the multicomponent one-pot synthesis of heterocyclic compounds were thoroughly investigated. The present study gives an efficient method for the one-pot three-component synthesis of poly substituted pyridine derivatives by the cyclo-condensation of aromaticaldehyde, malononitrile and substituted phenols in the presence of magnetically recoverable nano copper ferrite catalyst. This method involve simproved advantages like low percentage of catalyst used, lesser reaction times, higher yields ,magnetic recoverability and reuse of the catalyst, which makes it an environmentally benign process.